The Strait of Sicily (also known as Sicilian Strait, Sicilian Channel, Channel of Sicily, Sicilian Narrows and Pantelleria Channel; Italian: Canale di Sicilia or the Stretto di Sicilia; Sicilian: Canali di Sicilia or Strittu di Sicilia, Arabic: مضيق صقلية Maḍīq Ṣiqillīyah or مضيق الوطن القبلي Maḍīq al-Waṭan al-Qiblī) is the strait between Sicily and Tunisia. The strait is about 145 kilometres (90 mi) wide and divides the Tyrrhenian Sea and the western Mediterranean Sea, from the eastern Mediterranean Sea. The maximum depth is 316 meters (1,037 ft).

Deep currents in the strait flow from east to west, and the current nearer the surface travels from west to east. This unusual water flow is of interest to oceanographers.

There are regular ferries between Sicily and Tunis across the Strait of Sicily.

The island of Pantelleria lies in the middle of the strait.

The Strait of Sicily is located between, at the eastern side, Tunisia and the Malta Bank and on the northern side, Sicily, Italy. Within the Central Mediterranean sea it is one of the topographically complex regions. With a length of 600 km it connects the Eastern and Western Mediterranean basins. The strait is delimited by two systems; at the eastern side it is connected with the Ionian Sea, south of the Malta Bank with a sill of 560 m deep, and, on the western side, two passages connect the strait with the Western Mediterranean basin. The passage or channel more closely to Sicily is narrow and around 430 m deep while the channel at the side of Tunisia is broader and shallower with a maximum depth of 365 m. Due to this particular bathymetry with two different channels, the strait is called a "two-sill strait". In the central region the strait is around 50 km to 100 km wide and 700 m to 900 m deep, but some parts consist of trenches of even 1800 m deep.

A tunnel is proposed to link Tunisia and Sicily as nowadays ferries cross the Strait regularly.